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Arih2 gene

WebGene names i Name: Arih2 Imported Information which has been imported from another database using automatic procedures. WebARIH2 is part of cluster 5 Non-specific - Unknown function with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster.

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Webdownstream steps of the pathway. Loss of the ubiquitin E3 ligase Arih2 elevates the cellular level of Smo, causes Smo to inappropriately localize to cilia at the at the basal state, and elevates basal expression of Hedgehog responsive genes. Mice express two isoforms of Arih2 with different N-termini, but neither isoform localizes to cilia. WebE3 ubiquitin-protein ligase ARIH2 Arih2 Ari2, Triad1, Uip48 . 492: Annotation score: A0A0A6YXB0: A0A0A6YXB0_MOUSE: RBR-type E3 ubiquitin transferase. Arih2. 318: Annotation ... Gene expression databases. Bgee i: ENSMUSG00000064145, Expressed in cleaving embryo and 312 other tissues: ExpressionAtlas i: challenger 32l backpack https://hickboss.com

Tissue Cell Type - ARIH2 - The Human Protein Atlas

Web20 feb 2024 · We previously found the ARIH2 gene was repressed by HoxA9 in myeloid progenitors, but activated by HoxA10 during granulopoiesis. ARIH2 encodes the Triad1 protein, an anti-proliferative E3 ... WebShowing tissue cell type specific RNA data of ARIH2 (TRIAD1). We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... ARIH2: Gene description i. Ariadne RBR E3 ubiquitin protein ligase 2: Protein class i Enzymes: Predicted ... WebARIH2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. happy gilmore apology to chubbs

ARIH2 Gene - GeneCards ARI2 Protein ARI2 Antibody

Category:ARIH2 regulates the proliferation, DNA damage and ... - Nature

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Arih2 gene

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Web25 nov 2012 · The E3 ligase ARIH2 has an unusual structure and mechanism of elongating ubiquitin chains. To understand its physiological role, we generated gene-targeted mice deficient in ARIH2. Web4 set 2024 · Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation. HOXA10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response that was characterized by tissue infiltration with granulocytes, but reversed by re-expression of Triad1 in the bone marrow.

Arih2 gene

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WebFurthermore, loss of ARIH2, which is able to increase METAP2 protein level, also increased nascent protein synthesis upon EGFR inhibition (Figure 6H). Together, these data suggest that ARIH2 loss confers resistance to EGFR inhibition, at least in part, by maintaining higher protein synthesis rate through METAP2. WebSequence variants and/or copy number variants (deletions/duplications) within the ARIH2 gene will be detected with >99% sensitivity. Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported. Benign and likely benign variants are generally not reported.

Web24 set 2024 · PDF ARIH2, as an E3 ubiquitin ligase, is one of the important factors involved in regulating biological functions, such as inflammation and skeletal... Find, read and cite all the research you ... WebLoss of ARIH2 caused dysregulated activation of the transcription factor NF-κB in DCs, which led to lethal activation of the immune system in ARIH2-sufficent mice reconstituted with ARIH2-deficient hematopoietic stem cells. Our data have therapeutic implications for targeting ARIH2 function.

WebNM_006321.4(ARIH2):c.199A>C (p.Lys67Gln) Cite this record. Cite this record Close. Copy. Help Interpretation: Uncertain significance Review status: criteria provided, single submitter Submissions: 1 First in ... WebSingle cell type specificityi. The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more.

Web20 feb 2024 · Loss of the ubiquitin E3 ligase Arih2 elevates the cellular level of Smo, causes Smo to inappropriately localize to cilia at the at the basal state, and elevates basal expression of Hedgehog responsive genes. Mice express two isoforms of Arih2 with different N-termini, but neither isoform localizes to cilia.

WebARIH2 - ariadne RBR E3 ubiquitin protein ligase 2 The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in … challenger 337ga graphite vipWeb4 set 2024 · Gene ID: 23807, updated on 4-Sep-2024. Summary Other designations. E3 ubiquitin-protein ligase ARIH2, ARI-2, RING-type E3 ubiquitin transferase ARIH2, ariadne 2, ariadne homolog 2, protein ariadne-2 homolog, ubcM4-interacting protein 48. GeneRIFs: Gene References Into Functions. Arih2 regulates Hedgehog signaling through … happy gilmore and shooter mcgavinWebArih2 Gene Detail Summary Symbol. Arih2 Name. ariadne RBR E3 ubiquitin protein ligase 2. Synonyms. TRIAD1 Feature Type. protein coding ... Gene Model ID Feature Type Coordinates Select Strains; C57BL/6J: MGI_C57BL6J_1344361: protein coding gene: Chr9:108480141-108531917 (-) 129S1/SvImJ: challenger 32 gallon pressure tankWebMy Genes Showing 25 of 4,546 Results for ARIH2 Search Time: 0 ms Showing 25 50 100 200 500 See All of 4,546 Results for ARIH2 Search Time: 0 ms happy gilmore bucket hat/manual/evidences#ECO:0000313 happy gilmore bloomington indianaWeb21 mar 2024 · Complete information for lnc-ARIH2-3 gene (RNA Gene), , including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium challenger 32 specsWebVan der Reijden et al. (1999) identified ARIH2, which they termed TRIAD1, a 493-amino acid nuclear protein upregulated during retinoic acid-induced granulocytic differentiation of acute promyelocytic leukemia cells. ARIH2 contains 2 RING fingers flanking a conserved cysteine-rich (C6HC) domain the authors designated DRIL (double RING finger ... challenger 328 occasion