WebJan 8, 2024 · Borealin和蛋白磷酸酶PP2A可以同时与Sgo1的卷曲结构域结合,提示Sgo1可以整合Borealin和PP2A的活性来调节Aurora B底物的磷酸化。Borealin蛋白能够促 … Web靶向Xklp2靶蛋白(TPX-2)是一个受细胞周期严格调控的细胞核增殖蛋白,参与细胞有丝分裂的纺锤体微管功能,近年研究认为Aurora-B和TPX-2可能在肿瘤形成和进展中有重要促进作用〔5,6〕。本实验检测结肠腺癌组织Aurora-B和TPX-2的表达,分析其临床意义。 1 资料与方法
Borealin在肿瘤中的作用及其分子机制研究进展_参考网
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Chromatin protein HP1 interacts with the mitotic …
WebAlgorithm. Algorithm Quick BLASTP (Accelerated protein-protein BLAST) Algorithm blastp (protein-protein BLAST) Algorithm PSI-BLAST (Position-Specific Iterated BLAST) Algorithm PHI-BLAST (Pattern Hit Initiated BLAST) Algorithm DELTA-BLAST (Domain Enhanced Lookup Time Accelerated BLAST) Choose a BLAST algorithm Help. WebThe chromosomes in the oocytes of many animals appear to promote bipolar spindle assembly. In Drosophila oocytes, spindle assembly requires the chromosome passenger complex (CPC), which consists of INCENP, Borealin, Survivin, and Aurora B. To determine what recruits the CPC to the chromosomes and its role in spindle assembly, we … WebMay 11, 2012 · Biochemical reconstitution of the RanBP2/RanGAP1*SUMO1/Ubc9 complex enabled us to characterize its activity on the endogenous substrate Borealin. We find that the complex is a composite E3 ligase rather than an E2-E3 complex, and demonstrate that complex formation induces activation of a catalytic site that shows no activity in free … chemin fond ecran windows