2024 Klf4 chip-seq

Klf4 chip-seq

Author: zejq

August undefined, 2024

WebJun 5, 2014 · Analysis of Tcf3 genomic binding sites through chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq) reveals that Gsk3 signaling inhibition alleviates Tcf3-mediated transcriptional repression of … WebFeb 3, 2015 · A genome-wide RNA-seq analysis was conducted to identify genes regulated by KLF4 in T-ALL cells. Chromatin immunoprecipitation (ChIP) PCR was used to determine direct binding sites of KLF4 in T-ALL cells. Here we reveal that KLF4 induced apoptosis through the BCL2/BCLXL pathway in human T-ALL cell lines and primary T-ALL specimens.

Deciphering a Message from the Nucleus: How Transcription …

WebJul 17, 2024 · Remarkably, we provide evidence that Klf4 and Oct4 control nearly opposite patterns of gene expression in SMC and based on in vivo ChIP-seq analyses have … WebApr 1, 2024 · Results of in vivo KLF4 ChIP-Seq analyses, and studies in cultured SMC treated with cholesterol identified > 800 KLF4 target genes including many that regulate pro-inflammatory responses of SMC. Results indicate that the contribution of SMCs within atherosclerotic plaques has been greatly underestimated, and that KLF4-dependent … allrounder pzo triticale

Structurally-discovered KLF4 variants accelerate and …

WebJan 19, 2024 · GEO help: Mouse over screen elements for information. Cooperative binding of Oct4, Sox2, and Klf4 with stage-specific transcription factors orchestrates reprogramming [ChIP-seq] Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To gain a mechanistic understanding of their function, we mapped OSKM-binding, stage … WebDec 7, 2024 · with KLF4-ChIP seq data, we observed KLF4 binding en-richment at transcription start sites (TSSs) of more than. 50% of genes that were signi cantl y changed in NPCs com-pared with ESCs (fold ... WebAug 23, 2024 · KLF4 interacts with the SWI/SNF nucleosome remodeling complex to increase chromatin accessibility Having established that loss of KLF reduces chromatin … allrounder scarpe donna

KLF4 Gene - GeneCards KLF4 Protein KLF4 Antibody

KLF4 is involved in the organization and regulation of

WebKruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of … WebAnti-KLF4, Cat. No. ABE2860, is a highly specific rabbit polyclonal antibody that targets Krueppel-like factor 4 (Klf4) and has been tested for use in ChIP-seq, Chromatin Immunoprecipitation (ChIP), Immunoprecipitation, and Western Blotting. - Find MSDS or SDS, a COA, data sheets and more information. all rounder significadoWeb( c) Heat maps of KLF4, ZNF750, and CTCF ChIP–seq signal on day 3 at enhancers with gained H3K27ac signal. ( d) Box-and-whisker plots representing relative H3K27ac ChIP–seq signal in control versus transcription factor–knockdown conditions, for two biological replicates of each knockdown. all rounder potato biscuit

"WebMay 10, 2024 · Remarkably, the analysis of KLF4-ChIP-seq data revealed a much larger fraction of the promoter and enhancer regions of Agos_sDEGs that were bound by KLF4 … " - Klf4 chip-seq

Klf4 chip-seq

KLF4 recruits SWI/SNF to increase chromatin …

Web2 days ago · RNAPII ChIP-seq from GSE98605 . n = 3 merged replicates per condition, shown as a single heatmap. 43,152/45,518 RNAPII ChIP-seq peaks directly overlapped a called “consensus” OLDN peak (94.8%). Gel-extracted libraries were used for these analyses and size-selected for fragments between 230–270 bp. Data were analyzed for …

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WebSep 23, 2024 · Chromatin immunoprecipitation-sequencing (ChIP-seq) analysis showed two major categories of KLF4 binding sites: sites that were enriched during the intermediate … WebJul 10, 2024 · KLF4 ChIP-Seq. We demonstrated, using KLF gain-and-loss-of-function experiments, that KLF is required to mediate chromatin accessibility changes at proximal and distal sites, adding to the known role for KLF in transcriptional activation of flow responsive genes.

WebMay 29, 2024 · KLF4 plays multiple roles in normal physiology and disease. It is one of the Yamanaka factors that induce pluripotency in somatic cells ( Nandan and Yang, 2009 ). KLF4 also functions as a cancer driver gene ( Vogelstein et al., 2013 ), and is involved in cancer stem cell maintenance ( Leng et al., 2013; Yu et al., 2011; Zhu et al., 2014 ). WebDec 3, 2024 · RNA-seq and ChIP-Seq data that support the findings of this study have been deposited in the Gene Expression Omnibus under the accession code GSE111264 ... Consistent with this, I-BRD9-dependent reduction of Nanog and Klf4 expression was blunted when ESCs were cultured in 2i conditions ...

WebJan 21, 2024 · (A) Heat maps of peak distribution and the numbers of peaks from the ChIP-seq data of KLF4. (B) The distribution of ChIP-seq reads between -3kb and +3kb around TSS. (C) A Venn diagram of gene sets obtained from the comparison of ChIP-seq data of KLF4 among reprogramming MEF induced by KLF4 WT or L507A on day 2 or 10. Genes … WebFeb 25, 2013 · Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8) We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) …

WebKLF4 chromatin regulator Somatic tissue differentiation commonly requires the coordinated and simultaneous repression of progenitor genes mediating the proliferative cell program in concert with the activation of tissue-specific differentiation genes. Epidermal tissue contains

WebApr 11, 2024 · Furthermore, the authors identified the Dlx3, Klf4, ... ChiP-seq analyses of the Dlx3 genome-wide binding showed predominance of the Dlx3 peaks in intergenic regions (47%) over the proximal promoters (15%), suggesting a role for Dlx3 in long-range chromatin interactions. Importantly, further correlation of the peaks enriched for both Dlx3 and ... all rotations in volleyballWebSep 3, 2024 · Using mice with podocyte-specific knockdown of Klf4, we conducted glomerular RNA-sequencing, tandem mass spectrometry, and single-nucleus RNA-sequencing to identify cell-specific transcriptional changes that … all rounder potatoesWebGO enrichment analysis of the RNA-seq and ChIP-seq results showed that genes regulated by TCF21 were associated with the categories ‘ECM organisation’ and ‘ECM’ (figure 3C, D), ... Klf4-Dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis. Nat Med 2024; 23:1176–90. 10.1038/nm.4400 [PMC free ... allrounder traduzioneWebWe reaffirm the results obtained from in silico and chromatin studies in SCC25 by ChIP-seq of KLF4 and identify ΔNp63 as a co-oncogenic driver of the cancer-specific gene … all round fun rattan furnitureWebDec 22, 2009 · The recent development of ultra-high-throughput RNA sequencing (RNA-Seq) technology holds the promise to provide more accurate gene expression measurements (1, 2).Compared with microarray, RNA-Seq is able to measure absolute concentration of transcripts ().Meanwhile, chromatin immunoprecipitation (ChIP) coupled with microarray … all round financial port macquarieWebMay 12, 2011 · ChIP-seq analyses of RAD21 reveal an ESC specific cohesin binding pattern that is characterized by CTCF independent co-localization of cohesin with pluripotency related transcription factors Oct4, Nanog, Sox2, Esrrb and Klf4. allroundo classicWebFeb 25, 2013 · A combinatorial approach of gene expression profiling and chromatin immunoprecipitation/deep sequencing (ChIP-Seq) analysis revealed many key EMT … allroundo® classic