Web20 jun. 2013 · Metformin is a hypoglycemiant drug prescribed for the treatment and control of the type 2 diabetes mellitus. Recently, the potential efficacy of this antidiabetic drug as an anticancer agent has been demonstrated in various mammalian cancer cells. Web1 jan. 2024 · Therefore, we initially identified metformin antitumor functions on human OS without any involvement of AMPK pathway. Taken together, these findings not only …
WO2024042944A1 - Composition for preventing, ameliorating, or …
Web17 sep. 2024 · The current study revealed that the novel antitumor mechanism of metformin is mediated by regulation of mitochondrial E3 ubiquitin protein ligase 1 … WebNaringenin (NAR) is a naturally occurring plant bioflavonoid present in citrus fruits and possesses a wide range of biological application including anticancer effects. However, its prominent application in cancer is limited due to its suboptimal pharmacokinetics and poor bioavailability at the tumor sites. The aim of the present study was to develop naringenin … crystal light windows
Metformin sensitizes leukemic cells to cytotoxic lymphocytes by ...
Web8 apr. 2024 · In this review, we aim to highlight the importance of MCT over conventional chemotherapeutic approach with emphasis on nanoformulations-based MCT, their mechanism, challenges, recent advances, and future perspectives. Nanoformulations-based MCT revealed remarkable antitumor activity in both preclinical and clinical settings. Web1 dec. 2015 · Better understanding of mechanisms of metformin resistance will be crucial for metformin to be used as an effective anticancer agent. ... Myers R, Li Y, Chen Y, … WebBiguanides, including phenformin (Phen), metformin (Met), and so on, have been widely used throughout the world to treat type II diabetes. 6,7 These agents exert an antitumor effect on many cancers, including glioma, according to recent epidemiological surveys and laboratory studies. 8,9 To reveal the mechanism of antitumor activity of biguanides, … crystal light wild strawberry