WebDrug-induced nephrotoxicity represents an important cause of acute kidney injury with associated patient morbidity and mortality and is often responsible for termination of drug development, after extensive resource allocation. We have developed a human kidney tubuloid system that phenocopies, in 3D culture, kidney proximal tubules, a primary injury … Web18. nov 2024 · The SPAAC reaction for the ligation of oligonucleotides is exceptionally robust and universal and has been further explored by Kyriazi et al.102 to fabricate stable …
Spherical nucleic acids as an infectious disease vaccine platform
Web28. jún 2016 · SNAs can be designed to engage toll-like receptors (TLRs) (which control immunity in living cells) and modulate the innate immune system 10 to 100,000 times more effectively than linear nucleic acids. … Web30. mar 2024 · Cell-selective regulation of protein translocation is achieved through the rational design of an endogenous enzyme-operated spherical nucleic acids platform. The system enables enzyme-activated capture of proteins of interest and thus regulation of their cytoplasmic-nuclear shuttling with tumor-cell specificity, as reported by Mengyuan Li and … haircuts for women with glasses
DNA nanoclew templated spherical nucleic acid for siRNA delivery
WebThis animation describes the structure, properties, and uses of the spherical nucleic acid (SNA), a construct typically composed of a nanoparticle core and d... Web8. júl 2024 · Although the strategy of therapeutic vaccination for the treatment of prostate cancer has advanced to and is available in the clinic (Sipuleucel-T), the efficacy of such therapy remains limited. Here, we develop Immunostimulatory Spherical Nucleic Acid (IS-SNA) nanostructures comprised of CpG oligonucleotides as adjuvant and prostate cancer … Web4. apr 2024 · Called a spherical nucleic acid (SNA) vaccine, the technology consists of globular DNA nanoparticles that contain a DNA sequence that can stimulate the immune … haircuts for women round face